Tag Archives: rheological

Thyroid and periodontitis

16Mantskava M.

 

The modern world is increasing every year the number of people with thyroid dysfunction. It is necessary to pay attention to the children (11-15 yars old).  5% of this population is patient with thyroid dysfunction. At this age, most developing first and second stage of periodontal disease. Population rheological studies suggest that periodontitis when compared with the control hemorheological status is changed to 15%,  that thyroid dysfunction when compared with the control hemorheological status is changed to 30%. Rheological status   in patients with thyroid dysfunction and periodontal disease is even more variability. The book details shows the effect of the formation periodontal disease during thyroid dysfunction.

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Hemorheological Disorders and Arteriolar Resistance During Ischemic Heart Disease

68T. Urdulashvili,  N. Momtselidze,
M. Mantskava, N. Narsia,
G. Mchedlishvili.

 

Microcirculation research Center, I.Beritashvili Institute of Physiology, Tbilisi, Georgia.
Internal Medicine, State medical University, Tbilisi, Georgia.

 

Abstract. It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, which a technique that provided us with the direct and quantitative data. Simultaneously we investigated in the some patients the tone of the resistance arteries of the hand with an original non-invasive technique. We found that the erythrocyte aggregability increased almost twice in the blood of investigated patients as compared to the healthy control group. The aggregability was positively correlated with severity of the disease.

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The most pronounced hemorheological disorders were found in the patients with the heart failure. As to the arteriolar resistance index, it was increased only in 45 per cent of all the investigated patients and no significant difference between the patients with the heart failure and without it was found available. We concludes that the blood rheological disorders represent themselves a factor that plays a significant role in pathogenesis of development of the heart disease.[/su_animate]

Direct Beneficial Effect of Insulin on Blood Rheologiacal Disorders in the Microcirculation

66Maya Mantskava, Nugzar Pargalava, 
George Mchedlishvili.


Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.
N, Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.

 

Abstract. Under both in vivo and in vitro conditions we investigated effect on the most significant factor disturbing the blood rheological disorders in the microcirculation, the red blood cell aggregability. The in vivo studies we carried out in the 42 insulin treated diabetic patients (diabetes mellitus type II), as well as conducted the in vitro investigations of the blood both of the diabetic patients (24) and of the healthy people (20) where the insulin was added to the blood in vivo.
   
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The RBC aggregability in blood investigated with the “Georgian technique” was found significantly enhanced, by about 100 per cents in the diabetic patients. Under the in vivo conditions insulin administrated intravenously decreased the RBC aggregability almost to the normal level in diabetic patients. In addition, in vitro studies we found that the insulin lowered significantly the RBC aggregability when it was significantly enhanced by addition of Dextran-500, as well as in the blood of patients with the ischemic brain infarcts. The decreasing effect on the aggregability was observed even in the healthy control group where the RBC aggregability was in a normal range.[/su_animate]

Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene

30M. Mantskava., N. Momtselidze.,
N. Pargalava., G., Mchedlishvili.

 


Clinical hemorheology and microcirculation 2006;35(1-2):307-10.


 

Abstract

 

 

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The aim of the present study was to evaluate blood rheological disorders, in particular RBC enhanced aggregation, and compare changes in these parameters in patients with type 1 and 2 diabetes mellitus. For evaluation of RBC aggregability in the present study we applied the "Georgian technique", which was developed and applied for several years in our laboratory. Its advantage is that it is a direct and quantitative method. In all the investigated patients, diabetes mellitus was complicated with the foot gangrenes.[/su_animate]

Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene

73Maya Mantskava, Nana Momtselidze,  Nugzar Pargalava, George Mchedlishvili.


Microcirculation Research Center, I. Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia
N. Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia

 

Abstract. The aim of the present study was to evaluate blood rheological disorders, in particular RBC enhanced aggregation, and compare changes in these parameters in patients with type I and II diabetes mellitus. For evaluation of RBC aggregability in the present study we applied the “Georgian technique”, which was developed and applied for several years in our laboratory. Its advantage is that it is a direct and quantitative method. In all the investigated patients, diabetes mellitus was compared with the foot gangrenes. The patients were divided into two groups: (a) with type I and with type II diabetes mellitus. We matched the RBC aggregability indices in both groups of diabetic patients and compared the obtained results with those in the healthy control group. We found that rheological disorders were considerably pronounced.

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The RBC aggregability index increased by 62 per cent (p<0.001) in type I and by 57 per cent (p<0.001) in type II diabetic patients as compared to the control group. However, there were insignificant differences of the RBC aggregability changes between the two groups of the patients. Therefore we conclude that blood rheological disorders are similar in both types of diabetes mellitus. The disturbed blood fluidity related to the increased RBC aggregability in the microcirculation promotes, in particular, the development of the gangrene in both types of diabetes mellitus.Text[/su_animate]

Blood rheological status in obstruction apnea

60 M. Mantskava, G. Azikuri,
N. Momtselidze, N. Mitagvaria.

 

 

I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia

 

Summary

Sleep apnea is an independent pathology and a powerful stress for the organism. Apnea affects different systems. 44 patients with obstructive apnea (age 45.4±5 years) were under observation. Control group consisted of healthy subjects aged 36.3±5 years. Rheological status in the group of patients was as follows: RBC aggregability index – 42.7±7.2, RBC deformability index was 2.23±0.06, plasma viscosity – 1.27±0.03 and Hct – 39±5. The same parameters in the control group were: RBC aggregability index – 25.0±3.0, RBC deformability index – 2.23±0.02, plasma viscosity – 1.25±0.02, Hct – 45±3. The obtained data allow to recommend clinicians include disaggregants in standard treatment of obstructive sleep apnea.

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Blood rheological properties in blood loss (An experimental study)

69M. M. Mantskava, N. G. Momtselidze,
L. Sh. Davlianidze.

 

I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia; 14, L. Gotua, Tbilisi, Georgia

Blood loss is a complex pathological process with the mechanism that has not been fully unstudied. Blood rheology.biz is a particular link that is involved in blood losses. Objective: to perform a comprehensive study of blood rheological proper- ties, such as erythrocyte aggregability, erythrocyte deformability, plasma viscosity, and packed cell volume, in different degrees of experimental blood loss. [su_animate type=”bounceInDown”]

Materials and methods. Blood loss of different stages was simulated in anesthetized animals. The Georgian technique, membrane filtration, a capillary method, and a standard centrifugation method were used to study blood rheological properties. [/su_animate]

Question-answer

64

What determines blood rheological properties?

Hemorheological parameters determine blood rheological properties.

What determines blood rheological status?

1. Hematocrit.

2. Blood viscosity.

3. Еrythrocyte agregability.

4. Erythrocyte deformability.

What is the danger of causing rheological disorders?

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Increased erythrocyte aggregation, decreased erythrocyte deformation, changed hematocrit and plasma viscosity leads to a blockage of capillaries, a slowed down blood flow and develops a capillary stasis. The result is a lack of oxygen. During erythrocyte aggregation erythrocytes may get damaged and an erythrocyte coagulation factor may be developed, which could cause a rheological catastrophe.[/su_spoiler]

Study of hemorheological parameters at hemorrhagic shock

19M. Mantskava, N. Momtselidze,
L. Davlianidze.

 

I.Beritashvili Center I.Beritashvili Center Of Experimental Biomedicine, Tbilisi, Georgia


Nervous system is concerned to be a structure consisted of dynamic glio-neuro-synaptic networks that are able to morphological and functional modulation under external stimuli. Hemorheological shock is a external stimuli and stressor for brain.

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A particular link, which is involved in various stages of hemorheological shock, is blood rheology.biz. The aim of our work was a comprehensive rheological properties of blood: red blood cell aggregation, deformation of erythrocytes, plasma viscosity, hematocrit at different degrees of severity of experimental hemorrhagic shock. [/su_animate]

Stress – cause and effect hemorheological disorders

15Mantskava M., Momtselidze N.

Lambert academic  Publishing ISBN 978-3-659-66518-9), 2014 www.lap-publishing.com  –77 стр.

The book examines various rheological aspects of the different etiology  stress. Hemorrhagic shock occurring at blood loss appears to be a powerful stress for the organism. The origin (emergence) and spread of stress reactions are characterized by the features of the macro-and microcirculation. In stressful situations the crisis of blood circulation affects the functions of hemorheological disorders, as well as appears to be a consequence of the shock. We were the first to combine these two problems.  

There is a maximum possible rate of adaptive energy consumption and at this maximum the organism cannot cope with any additional stimulus. At the same time adaptive and stress diseases develop. Let’s consider the duration and manifestation of Raynaud's disease from the perspective of adaptation diseases and diseases of the third grade, which appears to be the cause of the double stress effect — cold and emotional- physical and psychic.

Sleep apnea is a independent pathology and a powerful stress for the organism. Apnea is a cause of stress and strengthens the body under stress. We propose a new marker for apnea: platelet composes.

Our data in this book have practical significance for biomedicine.

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