Tag Archives: flow

Coparative significance of the principal factors responsible for microcirculatory disirders in type 2 diabetes mellitus

61M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.

I.Beritashvilis institute of Physiology, Georgian Academy of Sciences, Tbilisi, Georgia
N. Bochua Georgian Center of Angiology and Vascular Surgery, Tbilisi, Georgia


The present study was aimed at investigating the comparative +changes of the two most significant microcirculatory factors if microvascular blood flow, possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus. By using direct quantitative and highly sensitive investigation techniques we found that insulin improves the blood rheological properties in the microcirculation altered during diabetes.
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However, when the disorders are strongly pronounced, due to enhanced red blood cells (RBC) aggregation, e.g., during development of the feet diabetic gangrene, the insulin becomes inefficient. As to the arteriolar tone, it seems to play less significant role in the pathogenesis of microcirculatory disturbances in diabetic patients.[/su_animate]

Comparative significance of the principal factors responsible for microcirculatory disorders in type 2 diabetes mellitus

20M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.

 

The present study was aimed at investigated the comparative changes of the two most significant microcirculatory factors of microvascular blood flow. Possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus.

 

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By using direct quantitative and highly sensitive investigation techniques we found that insulin improves the blood rheological properties in the microcirculation altered during diabetes. However, when the disorders are strongly pronounced, due to enhanced red blood cells (RBC) aggregation, e.g., during development of the feet diabetic gangrene, the insulin becomes inefficient. As to the arteriolar tone, it seems to play less significant role in the pathogenesis of microcirculatory disturbances in diabetic patients.
Key words: Erythrocyte aggregation, diabetes mellitus, resistance of arterioles
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Comparative values of erythrocyte aggregability versus other indices of hemorheological disorders in patients with ischemic brain infarcts

22G. Mchedlishvili,  R. Shakarishvili,
N. Momtselidze, L. Gobejishvili,
M. Aloeva,  M. Mantskava.

 


Microcirculation Research Center, I. Beritashvili Institute of Physiology, Tbilisi, Georgia. Clinical hemorheology and microcirculation (Impact Factor: 3.4). 02/2000; 22(1):9-15.
Source: PubMed

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ABSTRACT The aim of the present study is comparison of changes of principal hemorheological factors responsible for blood flow disorders in the microcirculation in patients with ischemic brain infarcts. It was found that in venous blood samples the erythrocyte aggregability (examined with a direct, highly sensitive, quantitative technique) was considerably more increased (by mean of 120%) than the blood plasma fibrinogen contents, blood plasma viscosity, and hematocrit which increased only by 23.7%, 7.4% and 3.6%, respectively, as compared to the same hemorheological factors in the healthy controls. [/su_animate]

Arteriolar resistance and hemorheological disorders related to raynaud’s phenomenon

24George Mchedlishvili, Maia Mantskava, Nugzar Pargalava.
 

Microvascular Research DOI: 10.1006/mvre.2001.2335
Volume 62, Issue 2, September 2001, Pages 190–195.


Abstract

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The functional condition of resistance arteries in human hands was monitored with a noninvasive test. Blood flow velocity changes (Doppler flow meter) were monitored in the radial artery before and after a 1-min stop flow in the hand under conditions of stable systemic arterial pressure. In addition, the most significant parameter of hemorheological disorders in microcirculation, RBC aggregability, was investigated in the same patients' blood samples.[/su_animate] 

Bood hemorheological status Bood hemorheological status during arterial hypertension

55M. Mantskava, N. Momtselidze.

Microcirculation is an important part of blood flow. It provides adequacy of blood suppy in organs and tissues. The newset method of biomedicine is a joint study of microcirculation and hemoreology. There is no pathologycal preocess where homoreological studies are not informative. Studies, data and conclusions persented in the book confirm the necessity of studying rheological features during arterial hypertansion treatment.

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