Tag Archives: erythrocyte

Comparative values of erythrocyte aggregability versus other indices of hemorheological disorders in patients with ischemic brain infarcts

22G. Mchedlishvili,  R. Shakarishvili,
N. Momtselidze, L. Gobejishvili,
M. Aloeva,  M. Mantskava.


Microcirculation Research Center, I. Beritashvili Institute of Physiology, Tbilisi, Georgia. Clinical hemorheology and microcirculation (Impact Factor: 3.4). 02/2000; 22(1):9-15.
Source: PubMed

[su_animate type=”rollIn”]

ABSTRACT The aim of the present study is comparison of changes of principal hemorheological factors responsible for blood flow disorders in the microcirculation in patients with ischemic brain infarcts. It was found that in venous blood samples the erythrocyte aggregability (examined with a direct, highly sensitive, quantitative technique) was considerably more increased (by mean of 120%) than the blood plasma fibrinogen contents, blood plasma viscosity, and hematocrit which increased only by 23.7%, 7.4% and 3.6%, respectively, as compared to the same hemorheological factors in the healthy controls. [/su_animate]

Hemorheological disorders and arteriolar resistance during ischemic heart disease

26T. Urdulashvili., N. Momtselidze.,
M. Mantskava., N. Narsia.,
G. Mchedlishvili.


Clinical hemorheology and microcirculation 2004;30(3-4):399-401.




[su_animate type=”bounceInUp”]

It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, with a technique that provided us with the direct and quantitative data.[/su_animate]



What determines blood rheological properties?

Hemorheological parameters determine blood rheological properties.

What determines blood rheological status?

1. Hematocrit.

2. Blood viscosity.

3. Еrythrocyte agregability.

4. Erythrocyte deformability.

What is the danger of causing rheological disorders?

[su_spoiler title=”Answer”]

Increased erythrocyte aggregation, decreased erythrocyte deformation, changed hematocrit and plasma viscosity leads to a blockage of capillaries, a slowed down blood flow and develops a capillary stasis. The result is a lack of oxygen. During erythrocyte aggregation erythrocytes may get damaged and an erythrocyte coagulation factor may be developed, which could cause a rheological catastrophe.[/su_spoiler]

Study of erythrocyte deformability at hemorrhagic shock

4M. Mantskava, N. Momtselidze,
L. Davlianidze.


I.Beritashvili Center of Experimental Biomedicine, 14 Gotua St., Tbilisi, Georgia, 0160.




[su_animate type=”lightSpeedIn”]

The aim of our work was a red blood cell deformation (rheological rheological ) at rheological degrees of severity of experimental hemorrhagic shock. The study of erythrocyte deformability violation and a compulsory monitoring of this physical value deserve more attention of fundamental and applied sciences. The modeling of hemorrhagic shock of different stages was performed in the group of anesthetized animals by means of standard blood discharge from the femoral artery (2,5 ml – first stage of shock; 5 ml – second stage of shock; 5ml – third stage of shock, n=12).[/su_animate]