Tag Archives: circulation

Positive Effect of Bemiparin to Blood Flow

71M. Mantskava, N. Momtselidze,
L. Davlianidze, T. Urdulashvili.



Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, 0160, Gotua St., 14, biomedicine.net@gmail.com;
Medical Centre “Medisoni”, Tbilisi, Georgia, 0182, Kaloubani St., 12



Coagulation and hemorheology play a significant role in blood circulation and ensure its trophic function. According to a modern concept it is impossible to develop physiological process if coagulation and blood rheology systems are not within the normal range. In the development of all pat-physiological processes coagulation and hemorheology play compensatory role, which is directed to adequacy and improvement of the tropic function. To study bemiparin we made research in vivo and in vitro systems. And found that bemiparin has a positive effect not only on the coagulation, but also on the rheological properties of blood.

Keywords: Bemiparin, Erythrocyte, Rheology, Microcirculation

Regional and systemic hemorheological disorders during feet diabetic gangrene

67Nugzar Pargalava, Maya Mantskava,
George Mchedlishvili.

N. Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.
Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.


Abstract. We investigated the RBC aggregability in the patients with the foot diabetic gangrene in the venous blood samples taken from the damaged foot before its amputation, as well as from the cubital vein (the systemic circulation). The RBC aggregability was investigated with the “Georgian technique” that is sensitive and provided us with direct and quantitative data.we found that the RBC aggregability was higher by about 20%, in the blood flowing from the gangrenous tissue than in the systemic circulation.

Key words: Microvascular hemorheology, diabetic gangrene, RBC aggregation.

Regional and systemic hemorheological disorders during feet diabetic gangrene.

28N. Pargalava., Maya Mantskava.,
George Mchedlishvili.


Clinical hemorheology and microcirculation 2004;30(3-4):457-9.


The Role of Various Stressors in the Trigger Mechanism of Raynaud’s Disease (Hemorheological and Vascular Reactions)


Mantskava M., Momtselidze N.,
Pargalava N.



I. Beritashvili Center for Experimental Biomedicine, Department of Blood Circulation and Metabolism, Tbilisi, Georgia, 0160.
Acad. N. Bokhua Center of Vascular and Heart Diseases, Tbilisi, Georgia, 0159.


Assessment of a functional condition of resistive arteries at the person

52G. Mchedlishvili, M. Mantskava,
T. Urdulashvili.


It is notable that the resistance arteries play the leading part in regulation of physiological parameters of the circulation system. It is proposed a new noninvasive method of appraisal of functional state of the human arm resistance arteries. The method is based on research of postischematic hyperemia arising as a result of standard stopping of local blood flow for one minute. The measurement of blood flow velocity in the radial artery of patients is performed by means of ultrasonic device which work is based on Doppler’s effect. For determination of functional state of the resistance arteries a new notion of resistance index is introduced. By this parameter the state of resistance arteries of human arm is investigated at different diseases (Raynaud’s phenomenon, arterial hypertension, diabetes mellitus, etc.).


Role of various stressor in the starting mechanism of an illness of Reynaud (haemo rheological and vascular reactions)

74Мantskava M., Momtselidze N.,
Pargalava N.


The emergence and spread of stress reactions are provided by the blood circulation system. In its turn, the adequacy of blood circulation depends on the hemorheological and vascular mechanisms. The changeability of their properties appears to be the basis of the increasing of stress stages. From the viewpoint of biophysical reactions, any change and movement occur with the expenditure and accumulation of energy. Higher level of adaptation energy waste and secondary level take place, when a small stressor entails a small expenditure.

There is a maximum possible rate of adaptive energy consumption and at this maximum the organism cannot cope with any additional stimulus. At the same time adaptive and stress diseases develop. Let’s consider the duration and manifestation of Raynaud's disease from the perspective of adaptation diseases and diseases of the third grade, which appears to be the cause of the double stress effect – cold and emotional- physical and psychic. Total of 97 patients with Raynaud's disease were examined. For a new vision of the problem it was necessary to find out how the streessors of various nature impact the hemoreheological status and vascular resistance.

Hemorhoelogical status during periodontitis and without thyroid dysfunction betwen children the age of 11-13

11Beriashvili Sesili Davidovna
 Postdoc; Georgian David the Builder University    
Mantskava Maia Mikhailovna
Associate Prof.; Beritashvili Biomedical Experimental Center, Tbilisi
Momtselidze Nana Gogievna
 Associate Prof.; Beritashvili Biomedical Experimental Center, Tbilisi
Nikolaishvuli Marina
 Associate Prof.; Beritashvili Biomedical Experimental Center, Tbilisi
Tupinashvili Tamar Nodarovna
 Postdoc; Georgian David the Builder University, Tbilisi
Tamasidze Nino Archilovna
Postdoc; Georgian David the Builder University, Tbilisi