Comparative significance of the principal factors responsible for microcirculatory disorders in type 2 diabetes mellitus
M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.
The present study was aimed at investigated the comparative changes of the two most significant microcirculatory factors of microvascular blood flow. Possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus.
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By using direct quantitative and highly sensitive investigation techniques we found that insulin improves the blood rheological properties in the microcirculation altered during diabetes. However, when the disorders are strongly pronounced, due to enhanced red blood cells (RBC) aggregation, e.g., during development of the feet diabetic gangrene, the insulin becomes inefficient. As to the arteriolar tone, it seems to play less significant role in the pathogenesis of microcirculatory disturbances in diabetic patients.
Key words: Erythrocyte aggregation, diabetes mellitus, resistance of arterioles.[/su_animate]
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