Blood rheological properties in blood loss (An experimental study)

69M. M. Mantskava, N. G. Momtselidze,
L. Sh. Davlianidze.

 

I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia; 14, L. Gotua, Tbilisi, Georgia

Blood loss is a complex pathological process with the mechanism that has not been fully unstudied. Blood rheology.biz is a particular link that is involved in blood losses. Objective: to perform a comprehensive study of blood rheological proper- ties, such as erythrocyte aggregability, erythrocyte deformability, plasma viscosity, and packed cell volume, in different degrees of experimental blood loss.

The data were analyzed applying the statistical programs Origin 4.1 (Microcat.Software.Inc) and Microsoft Excel. Results. In stages 1, 2, and 3 blood losses, erythrocyte aggregability was significantly increased by 10, 25, and 44% and erythrocyte deformability was decreased by 12, 13, and 15%, respectively, as compared to the controls. The delta viscosity was insignificant (both in the subgroups in different blood loss degrees versus the control group); the packed cell volume in blood loss was increased insignificantly as compared to the control. Conclusion. Comprehensive assessment of the degree of blood loss requires a minimum set of blood rheological indices, such as erythrocyte aggregability and deformability, blood viscosity, and packed cell volume. The basis for monitoring the rheological indices of massive blood loss is the specific features of erythrocyte aggregation. Key words: blood rheology.biz, erythrocyte aggregability, blood loss.

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Conclusion

The following hemorheological features of the blood were studied after the hemorrhage: an index of erythrocyte aggregation, an index of erythrocyte deformability, blood viscosity, hematocrit. It is assumed that it is real to carry out the investigations using any certified and licensed method. By estimating the rheo- logical parameter, spartucularly the erythrocyte aggre- gation, it is possible to refine an algorithm of intensive therapy and the diagnostics of massive hemorrhage that both would significantly contribute to the emergency medicine and reanimatology.[/su_spoiler]

Acknowledgement. Authors appreciate Shota Rustaveli Georgian National Scientific Fund (Grant FR/420/7-270/12) for support and Society for Shock Studies in Russia (SSSR), the members of which the research group of authors appears to be.

References

1.    Likhovetskaya Z.M., Prigozhina T.A., Gorbunova N.A. Gemoreologicheskie narusheniya pri shoke razlichnoi etiologii. [Hemorheologic disorders in shock of diverse etiology]. Byulleten Eksperimentalnoi Biologii i Meditsiny. 1988: 106 (10): 426—428. PMID: 3191229. [In Russ.]

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15.    Bishop J.J., Nance P.R., Popel A.S., Intaglietta M., Johnson P.C. Effect of erythrocyte aggregation on velocity profiles in venules. Am. J. Physiol. Heart Circ. Physiol. 2001; 280 (1): H222—H236. PMID: 11123237

 

         

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