Study of hemorheological parameters at hemorrhagic shock

19M. Mantskava, N. Momtselidze,
L. Davlianidze.

 

I.Beritashvili Center I.Beritashvili Center Of Experimental Biomedicine, Tbilisi, Georgia


Nervous system is concerned to be a structure consisted of dynamic glio-neuro-synaptic networks that are able to morphological and functional modulation under external stimuli. Hemorheological shock is a external stimuli and stressor for brain.

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A particular link, which is involved in various stages of hemorheological shock, is blood rheology.biz. The aim of our work was a comprehensive rheological properties of blood: red blood cell aggregation, deformation of erythrocytes, plasma viscosity, hematocrit at different degrees of severity of experimental hemorrhagic shock. [/su_animate]

The modeling of hemorrhagic shock of different stages was performed in the group of anesthetized animals by means of standard blood discharge from the femoral artery. For the diagnosis of blood rheological properties the “Georgian technique”, a method of membrane filtration, a capillary method and standard centrifugation method were used. According to our data, the aggregation was significantly increased by 10%, 25% and 44%, as compared to the control. The deformability decreased by 12%, 13% and 15% at the first, second and third stages of hemorrhagic shock, respectively. Delta viscosity was not significant (both within the subgroups – at various stages of shock, and also in comparison with the control), at hemorrhagic shock the hematocrit was unreliably increased as compared with the control. Consequently, at hemorrhagic shock an erythrocytic component, particularly, the aggregation of erythrocytes has a leading role. The analysis of the data was performed using statistical programs “Origin 4.1’’ (Microsoft. Software, Inc) and Microsoft Excel. Major role in hemorrhagic shock play erythrocyte composes, in particular, erythrocyte aggregation. Neuroplasticity is a natural property of a nervous system to form new synaptic connections in response to injury or external influence. New synaptic connections are formed in schok too. Probability study of hemorheological properties in shoke will shed light neurophysiological hypothesisin phemomena of neuroplasticity. Studying of pathophysiological mechanisms underlying neuroplasticity reveals broad therapeutic perspectives of recovery of lost functions and improvement of quality of life among the patients with diseases and injuries of nervous system.

Acknowledgment. Shota Rustaveli National Science Foundation (FR/420/7-270/12)

 

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