Category Archives: Library
INFLUENCE OF DIFFERENT BY DURATION insulin action on erythrocyte aggregation
Mantskava M.M.; Momtselidze N.G.; Urdulashvili T.A.
In modern pharmacology presented insulins different BY DURATION insulin: ultra-fast action, short-acting, intermediate-acting, long-acting insulins and mixed. This makes it possible to construct various circuits for diabet treatment. The aim of our work was to investigate INFLUENCE OF DIFFERENT BY DURATION insulin action on erythrocyte aggregation of red blood cells in patients with type I and type II and in vitro
Key words: insulin; diabetes mellitus, aggregation of red blood cells.
You will be able to study this article if you pass into the Russian department of the site and click on a tag of “RUS”.
NEW NON-INVASIVE METHOD FOR MEASURING COEFFICIENT ОF MICROCIRCULATION
M. M. Mantskava
I.Beritashvili Center of Experimental Biomedicine, 0160, Tbilisi, Georgia, L.Gotua St.14,
e-mail: mantskavamaka@rambler.ru
Annotation. The resistive arteries of blood circulatory system appear to be the subject for indirect diagnostic studies of microcirculatory channel. At not altered levels of general arterial and venous pressure, the blood flow velocity measured in the resistive arteries depends precisely on the state of the relevant resistive arteries, as a result of its branching. We used an ultrasonic device “Dop 8/4” (Germany) with four inputs for probes with built-in self-recorder. According to the dynamics of changes in blood flow velocity in the radial and posterior tibial arteries in all leads after standard ischemia during the development of post-ischemic hyperemia, the state of branching of the resistive arteries, as well as the blood filling of microcirculatory channel can be judged.For description of the reactions of resistive arteries in all leads, which control a peripheral resistance and microcirculation, the coefficient of microcirculation k has been introduced, which appears to be the ratio of the total post-ischemic blood flow to the average volumetric background blood flow.
Thyroid and periodontitis
Mantskava M.
The modern world is increasing every year the number of people with thyroid dysfunction. It is necessary to pay attention to the children (11-15 yars old). 5% of this population is patient with thyroid dysfunction. At this age, most developing first and second stage of periodontal disease. Population rheological studies suggest that periodontitis when compared with the control hemorheological status is changed to 15%, that thyroid dysfunction when compared with the control hemorheological status is changed to 30%. Rheological status in patients with thyroid dysfunction and periodontal disease is even more variability. The book details shows the effect of the formation periodontal disease during thyroid dysfunction.
[su_animate type=”wobble”]You will be able to study this article if you pass into the Russian department of the site and click on a tag of “RUS”.[/su_animate]
Positive Effect of Bemiparin to Blood Flow
M. Mantskava, N. Momtselidze,
L. Davlianidze, T. Urdulashvili.
Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, 0160, Gotua St., 14, biomedicine.net@gmail.com;
Medical Centre “Medisoni”, Tbilisi, Georgia, 0182, Kaloubani St., 12
t.urdulashvili@yahoo.com.
Abstract
Coagulation and hemorheology play a significant role in blood circulation and ensure its trophic function. According to a modern concept it is impossible to develop physiological process if coagulation and blood rheology systems are not within the normal range. In the development of all pat-physiological processes coagulation and hemorheology play compensatory role, which is directed to adequacy and improvement of the tropic function. To study bemiparin we made research in vivo and in vitro systems. And found that bemiparin has a positive effect not only on the coagulation, but also on the rheological properties of blood.
Keywords: Bemiparin, Erythrocyte, Rheology, Microcirculation
Hemorheological, microvascular and hemodynamic disorders during coronary heart disease
Urdulashvili T., Momtselidze N.,
Mantskava M., Narsia N.,
Mchedlishvili G.
Department of Internal Medicine, State Medical University; Microcirculation Research Center, I. Beritashvili Institute of Physiology, Tbilisi, Georgia.
Coronary artery disease (CAD) is the leading cause of cardiovascular mortality worldwide. Even more, it is projected that CAD mortality rates will double from 1990 to 2020, with approximately 82% of the increase attributable to the developing world [5]. Prevention and targeted control of risk factors for CAD could potentially reduce the impact of CAD in the developing world.
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Many scientists indicate the significance of the monitoring of hemorheological patterns during various forms of the ischemic heart disease [2,6]. The increased RBC aggregation was observed in the patients in the following order: unstable angina, acute myocardial inf- arct. The best correlation was observed by integration of large aggregate fraction as a function of shear stress [1].[/su_animate]
Parathyroid gland dysfunction and blood rheological changes in adolescents
M. Mantskava, S. Beriashvili,
N. Momtselidze, S. Zenaishvili,
M. Nikolaishvili, T. Tupinashvili,
I. Vashakidze.
Beritashvili Biomedical Experimental Center,
Georgian David the Builder University.
The thyroid gland disorders are the contributing factors to the development of periodontitis. Despite the lack of works, discussing the hemoreological and calcium, phosphorus homeostasis disorders, resulting in the destruction of the tooth hard tissue mineralization, their authors confirm the unity of the microcirculation disorders and thyroid dysfunction. Our data also confirm this statement. We believe that the imbalance, caused by parathormone, leads to microcirculation disturbances not only locally, but also to all organs and tissues.
[su_animate type=”rotateInUpLeft”]You will be able to study this article if you pass into the Georgian department of the site and click on a tag of “GE”.[/su_animate]
Hemorheological Disorders and Arteriolar Resistance During Ischemic Heart Disease
T. Urdulashvili, N. Momtselidze,
M. Mantskava, N. Narsia,
G. Mchedlishvili.
Microcirculation research Center, I.Beritashvili Institute of Physiology, Tbilisi, Georgia.
Internal Medicine, State medical University, Tbilisi, Georgia.
Abstract. It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, which a technique that provided us with the direct and quantitative data. Simultaneously we investigated in the some patients the tone of the resistance arteries of the hand with an original non-invasive technique. We found that the erythrocyte aggregability increased almost twice in the blood of investigated patients as compared to the healthy control group. The aggregability was positively correlated with severity of the disease.
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The most pronounced hemorheological disorders were found in the patients with the heart failure. As to the arteriolar resistance index, it was increased only in 45 per cent of all the investigated patients and no significant difference between the patients with the heart failure and without it was found available. We concludes that the blood rheological disorders represent themselves a factor that plays a significant role in pathogenesis of development of the heart disease.[/su_animate]
Coparative significance of the principal factors responsible for microcirculatory disirders in type 2 diabetes mellitus
M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.
I.Beritashvilis institute of Physiology, Georgian Academy of Sciences, Tbilisi, Georgia
N. Bochua Georgian Center of Angiology and Vascular Surgery, Tbilisi, Georgia
The present study was aimed at investigating the comparative +changes of the two most significant microcirculatory factors if microvascular blood flow, possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus. By using direct quantitative and highly sensitive investigation techniques we found that insulin improves the blood rheological properties in the microcirculation altered during diabetes.
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However, when the disorders are strongly pronounced, due to enhanced red blood cells (RBC) aggregation, e.g., during development of the feet diabetic gangrene, the insulin becomes inefficient. As to the arteriolar tone, it seems to play less significant role in the pathogenesis of microcirculatory disturbances in diabetic patients.[/su_animate]
Regional and systemic hemorheological disorders during feet diabetic gangrene
Nugzar Pargalava, Maya Mantskava,
George Mchedlishvili.
N. Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.
Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.
Abstract. We investigated the RBC aggregability in the patients with the foot diabetic gangrene in the venous blood samples taken from the damaged foot before its amputation, as well as from the cubital vein (the systemic circulation). The RBC aggregability was investigated with the “Georgian technique” that is sensitive and provided us with direct and quantitative data.we found that the RBC aggregability was higher by about 20%, in the blood flowing from the gangrenous tissue than in the systemic circulation.
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Therefore, the sources of the systemic hemorheological disorders were the primarily damaged tissues. Taking into account that the blood in uninterruptedly flowing and mixing together in the whole circulatory bed we conclude that in the systemic circulation a certain compensatory mechanism provide for a partial normalization of the blood rheological properties, since the RBC aggregability never reaches the level in the blood of the healthy people.[/su_animate]
Key words: Microvascular hemorheology, diabetic gangrene, RBC aggregation.
Direct Beneficial Effect of Insulin on Blood Rheologiacal Disorders in the Microcirculation
Maya Mantskava, Nugzar Pargalava,
George Mchedlishvili.
Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.
N, Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.
Abstract. Under both in vivo and in vitro conditions we investigated effect on the most significant factor disturbing the blood rheological disorders in the microcirculation, the red blood cell aggregability. The in vivo studies we carried out in the 42 insulin treated diabetic patients (diabetes mellitus type II), as well as conducted the in vitro investigations of the blood both of the diabetic patients (24) and of the healthy people (20) where the insulin was added to the blood in vivo.
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The RBC aggregability in blood investigated with the “Georgian technique” was found significantly enhanced, by about 100 per cents in the diabetic patients. Under the in vivo conditions insulin administrated intravenously decreased the RBC aggregability almost to the normal level in diabetic patients. In addition, in vitro studies we found that the insulin lowered significantly the RBC aggregability when it was significantly enhanced by addition of Dextran-500, as well as in the blood of patients with the ischemic brain infarcts. The decreasing effect on the aggregability was observed even in the healthy control group where the RBC aggregability was in a normal range.[/su_animate]
