Category Archives: Abstracts

ESM-EVBO joint meeting 2017 May 29-June 1st 2017, Geneva, Switzerland Relationship between vascular aging, patients’ age and age disease

Mantskava M., Momtselidze N., Gotsadze M.

Introduction.The major link of pathogeny of development of the vassels age-related changes is violation of microcirculation and hemorheology, which are the basis of physiological aging and changing under the influence of diseases. Practically healthy subjects that were subdivided into age-related groups took part in population researches. Methods.The 1st group: middle age – 40±4,5, n=15, 2 th group: middle age 70±5, n=15). We studied other groups of patients with the same age, but with hypertensive disease with age 5 years and 15 years: 3th group:middle age – 40±4,5, diasease age 5 years; 4th group:middle age – 40±4,5, diasease age 15 years; 5th group:middle age – 70±4,5, diasease age 5 years; 6th group:middle age – 70±4,5, diasease age 15 years.

Blood rheological changes during stroke in male and female groups  European Stroke Organization conference, Prague, Czech Republic, 16-18 May, 2017.

Mantskava M.


The aim of the present study was the comparative analysis of the role of specific hemorheological derangements in the pathogenesis of ischemic brain infarcts in women (I group) and group with male patients (II group). Blood plasma viscosity, as well as red blood cells (RBC) aggregability were quantitatively investigated in all patients during the study. Research blood rheological methods: Red blood cell (RBC) aggregation – «Georgian method» and the standart capillary method for  measurement of blood plasma viscosity. Both of the above mentioned indices of hemorheological disorders were significantly higher in the patients in II group as compared to the control and I group. During the ischemic stroke, blood plasma viscosity was increased by a mean of 7.2 per cent in the first and by a mean of 9.6 per cent in the second group of patients. As to the erythrocyte aggregability index, it was changed considerably more – by a mean of 123.8 per cent during stroke in male patients, while in femele patients the RBC aggregability index was found to be increased by a mean of 107.3 per cent. Ischemic brain infarcts in patients in I group and in II group were associated with a significant increase of the patients' blood rheological disorders in all the investigated cases.

 

 

Аggregation and adhesion of red blood cells, 13th International Conference on Pathology, June 26-27, 2017, San Diego, USA

Mantskava M.

Important for cell biology to study not only cell adhesion, but the aggregated cells. For example it is very important to study the aggregation of red blood cells. This is important from the viewpoint of biology research, and in terms of applied medicine. in the abstract, we describe a new improved method for the study of aggregation of cells, such as erythrocytes. Тhe index of erythrocytes aggregability, which represents aggregated erythrocytes area ratio against whole area of the erythrocytes. To this end we used the so-called “Georgian technique”. Erythrocyte aggregation was evaluated by using the “Georgian technique”. Blood samples were centrifuged and about 0.1 ml blood was diluted 1:200 in own plasma in the Thoma pipettes preliminary rinsed with 5% sodium citrate solution without addition of any other anticoagulants to the blood under study. Following standard mixing the diluted blood was placed into a glass chamber 0.1 mm high. The quantitative index of erythrocyte aggregation, which was assessed with a special program at the Texture Analysis System (TAS-plus, “Leitz, Germany), represented itself the relationship of the aggregated and unaggregated red cells.

 

 

Study of hemorheological parameters at hemorrhagic shock

19M. Mantskava, N. Momtselidze,
L. Davlianidze.

 

I.Beritashvili Center I.Beritashvili Center Of Experimental Biomedicine, Tbilisi, Georgia


Nervous system is concerned to be a structure consisted of dynamic glio-neuro-synaptic networks that are able to morphological and functional modulation under external stimuli. Hemorheological shock is a external stimuli and stressor for brain.

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A particular link, which is involved in various stages of hemorheological shock, is blood rheology.biz. The aim of our work was a comprehensive rheological properties of blood: red blood cell aggregation, deformation of erythrocytes, plasma viscosity, hematocrit at different degrees of severity of experimental hemorrhagic shock. [/su_animate]

Reological disorders with preeclampsia

17Mantskava M.,  Momtselidze N.


Berlin, Germany, 18-21 Mach, 2016 (16 World Congress on Human Reproduction)


The aim of the present study is comparison of changes of hemorheological functional condition responsible for blood flow disorders in the microcirculation in physiology pregnancy, pregnancy women with preeclampsia and control group. The principal factor of hemoreological was monitored RBC aggregation with the "Georgian technique" that is sensitive and provided us with direct and quantitative data. 

[su_animate type=”slideInLeft”]We investigated 25 subjects with mean age 25,5±3,4 (physiological first pregnancy, 21 weeks, n=10; first pregnancy with preeclampsia, 21 weeks, n=8; control, n=7).[/su_animate] 

Safety of treatment of various diseases

7Davlianidze L., Mantskava M.,
Pargalava N.

 


The center of experimental biomedicine of I. Beritashvili

 

 

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Blood rheological status during treatment of arterial hypertension

9Mantskava М.,  Мomtselidze Н.


 

The center to Experimental biomedicine of I. Beritashvili, Georgia, Tbilisi.


 

 

 

[su_animate type=”pulse”]You will be able to study this article if you pass into the Russian department of the site and click on a tag of "RUS".[/su_animate]

 

Influence ofdifferent types of insulin on the aggregation of red blood cells in patients with diabetes

8Mantskava М.,  Momtselidze Н.


 

The center of Experimental Biomedicine of I. Beritashvili,
Department of microcirculation and haemo rheology.biz, 0160, Georgia, Tbilisi, ul. L. Gotua, 14.

 

 

[su_animate type=”flipInY”]You will be able to study this article if you pass into the Russian department of the site and click on a tag of "RUS".[/su_animate]

 

Reological disorders with preeclampsia

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Mantskava M.,  Momtselidze N.


Berlin, Germany, 18-21 Mach, 2016 (16 World Congress on Human Reproduction)

 

The aim of the present study is comparison of changes of hemorheological functional condition responsible for blood flow disorders in the microcirculation in physiology pregnancy, pregnancy women with preeclampsia and control group.

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The principal factor of hemoreological was monitored RBC aggregation with the "Georgian technique" that is sensitive and provided us with direct and quantitative data.  We investigated 25 subjects with mean age 25,5±3,4 (physiological first pregnancy, 21 weeks, n=10; first pregnancy with preeclampsia, 21 weeks, n=8; control, n=7). The analysis of the data was performed using statistical [/su_animate]