Positive Effect of Bemiparin to Blood Flow

71M. Mantskava, N. Momtselidze,
L. Davlianidze, T. Urdulashvili.

 

 

Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, 0160, Gotua St., 14, biomedicine.net@gmail.com;
Medical Centre “Medisoni”, Tbilisi, Georgia, 0182, Kaloubani St., 12
t.urdulashvili@yahoo.com.


 

Abstract

Coagulation and hemorheology play a significant role in blood circulation and ensure its trophic function. According to a modern concept it is impossible to develop physiological process if coagulation and blood rheology systems are not within the normal range. In the development of all pat-physiological processes coagulation and hemorheology play compensatory role, which is directed to adequacy and improvement of the tropic function. To study bemiparin we made research in vivo and in vitro systems. And found that bemiparin has a positive effect not only on the coagulation, but also on the rheological properties of blood.

Keywords: Bemiparin, Erythrocyte, Rheology, Microcirculation

1. Introduction

    Two different systems that provide motion and movement of blood are involved simultaneously in human body [1]. This is coagulation/anticoagulation and rheological. Blood is not a homogeneous (Newtonian) liquid and it is a suspension having suspended particles, it has exceptional features and it is studied by coagulation and hemorheology. Coagulation and hemorheology play a significant role in blood circulation and ensure its trophic function [2]. Changes in coagulation and rheological properties of blood may cause a slowdown in the flow, establishment of stasis, thrombus, which is accompanied by multi-disease. Coagulation involves the formation of various substances which are produced as a genetically determined body components (primary anticoagulants) or arise in blood clotting and fibrinolysis (secondary anticoagulant). They distinguish physiological anticoagulant – a primary anticoagulants, constantly contained in the blood, the synthesis of which does not depend on the activity of the coagulation system in the body at the moment. These substances are released into the blood stream at a constant rate, where they interact with the active coagulation factors, causing their neutralization. On the basis of the above mentioned the blood remains in the form of liquid. They act solely on active forms of coagulation factors, whereas the inactive form factors (proenzymes or procoagulants) are not subjects for inactivation. Heparin belongs to the first anticoagulants. This is polysaccharide, which are synthesized by mast cells associated with endothelium that are main repository of heparin and vasoactive substances (histamine and serotonin), and granulocytes. A significant number is defined in the liver, heart, muscle, lung, and mast cells and basophiles. It does not have excess to the placenta. It is a polyvalent of inhibitor action that restricts all phases of coagulation [3].

Develop

Our research team has extensive experience in the study of the mechanisms of blood rheology and microcirculation. It was for the first time that the changes in blood flow during different types of diseases had been studied by us [19, 20, 21].  On the basis of the researches carried out in previous years different postulates have been presented for discussion by our research group. Clinicians and scientists represented the audience. Big number of our proposals gained practical responses and some clinics are guided by some of our recommendations at present. The conduction of the researches described in the project is very important and significant, in order to reveal the previously unknown features of bemiparin.

 

References

[1]. Kamensky A. and Kamkin A., 2004. Fundamental and Clinical Physiology. Academia, Moscow.

[2]. Hoffman M., Monroe D., 2006. Coagulation: A modern view of hemostasis. Hematology/Oncology Clinics of North America 21 (1), 1-11.

Develop

[20] Momtselidze N., Mantskava M., Mchedlishvili G., 2006. Hemorheological disorders during ishcemic brain infarcts in patients with and without diabetes mellitus. Clinical Hemorheology and Microcirculation. 35, 261-265.

[21] Mantskava M., .Momtselidze N., Pargalava N., Mchedlishvili G., 2006. Hemorheological disorders during the 1st and 2nd types of diabetes mellitus in patients with foot gangrenes. Clinical Hemorheology and Microcirculation. 35,  307-311.

 

         

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