Monthly Archives: November 2015

Hemorheological Disorders and Arteriolar Resistance During Ischemic Heart Disease

68T. Urdulashvili,  N. Momtselidze,
M. Mantskava, N. Narsia,
G. Mchedlishvili.

 

Microcirculation research Center, I.Beritashvili Institute of Physiology, Tbilisi, Georgia.
Internal Medicine, State medical University, Tbilisi, Georgia.

 

Abstract. It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, which a technique that provided us with the direct and quantitative data. Simultaneously we investigated in the some patients the tone of the resistance arteries of the hand with an original non-invasive technique. We found that the erythrocyte aggregability increased almost twice in the blood of investigated patients as compared to the healthy control group. The aggregability was positively correlated with severity of the disease.

Coparative significance of the principal factors responsible for microcirculatory disirders in type 2 diabetes mellitus

61M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.

I.Beritashvilis institute of Physiology, Georgian Academy of Sciences, Tbilisi, Georgia
N. Bochua Georgian Center of Angiology and Vascular Surgery, Tbilisi, Georgia


The present study was aimed at investigating the comparative +changes of the two most significant microcirculatory factors if microvascular blood flow, possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus. By using direct quantitative and highly sensitive investigation techniques we found that insulin improves the blood rheological properties in the microcirculation altered during diabetes.

Regional and systemic hemorheological disorders during feet diabetic gangrene

67Nugzar Pargalava, Maya Mantskava,
George Mchedlishvili.


N. Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.
Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.

 

Abstract. We investigated the RBC aggregability in the patients with the foot diabetic gangrene in the venous blood samples taken from the damaged foot before its amputation, as well as from the cubital vein (the systemic circulation). The RBC aggregability was investigated with the “Georgian technique” that is sensitive and provided us with direct and quantitative data.we found that the RBC aggregability was higher by about 20%, in the blood flowing from the gangrenous tissue than in the systemic circulation.

Key words: Microvascular hemorheology, diabetic gangrene, RBC aggregation.

Direct Beneficial Effect of Insulin on Blood Rheologiacal Disorders in the Microcirculation

66Maya Mantskava, Nugzar Pargalava, 
George Mchedlishvili.


Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.
N, Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.

 

Abstract. Under both in vivo and in vitro conditions we investigated effect on the most significant factor disturbing the blood rheological disorders in the microcirculation, the red blood cell aggregability. The in vivo studies we carried out in the 42 insulin treated diabetic patients (diabetes mellitus type II), as well as conducted the in vitro investigations of the blood both of the diabetic patients (24) and of the healthy people (20) where the insulin was added to the blood in vivo.
   

All entries on this site with the authors

M. Mantskava

Autor M. MantskavaMonographsArticlesAbstractsSummary of articles

 

Resistive arteries, normal function and pathological reactions

59 Мchedlishvili G., Tsinamdzgvrishvili B., Mantskava M.

Our studies have shown pathogenic resistive functional characteristics of arteries in the body, which provide a normal and an abnormal pressure in microcirculation of organs. Our studies have shown pathogenic characteristics of the functional state of resistive arteries in the body, which provide a normal and an abnormal pressure in  microcirculation of organs. Furthermore, our studies have shown  changes of тче smooth muscle of resistive arteries, which cause pathological constriction. Based on this data, we developed a technique to determine the functional state of the resistance arteries.

 

 

Microvascular and Hemorheological disorders during ischemic heart disease

18T. Urdulashvili, M. Mantskava,
N. Momtselidze, N. Narsia,
G. Mchedlishvili.

 

Scientific –Practical Journal ISSN 1512-1291.
Cardilogy and Internal Medicine XXIN4 (VIII) 2004, 9-15.


 

Significance of the hemorheological disorders in development of acute vascular syndromes is presenltky well known, but their role in pathogenesis of chronic ischemic heart disease is not yet sufficiently analyzed. Aim of the present study was investigation of the relationship between the hemorheological, vascular and hemodynamic factors during the ischemic heart disease.

Comparative significance of the principal factors responsible for microcirculatory disorders in type 2 diabetes mellitus

20M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.

 

The present study was aimed at investigated the comparative changes of the two most significant microcirculatory factors of microvascular blood flow. Possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus.

 

 

Hemorheological, microvascular and hemodynamic disorders during coronary heart disease

21Urdulashvili T., Momtselidze N.,
Mantskava M., Narsia N.,
Mchedlishvili G.

 


Georgian Med News.  2006; (136):55-7 (ISSN: 1512-0112)Department of Internal Medicine, State Medical University, Tbilisi, Georgia.

 

Comparative values of erythrocyte aggregability versus other indices of hemorheological disorders in patients with ischemic brain infarcts

22G. Mchedlishvili,  R. Shakarishvili,
N. Momtselidze, L. Gobejishvili,
M. Aloeva,  M. Mantskava.

 


Microcirculation Research Center, I. Beritashvili Institute of Physiology, Tbilisi, Georgia. Clinical hemorheology and microcirculation (Impact Factor: 3.4). 02/2000; 22(1):9-15.
Source: PubMed

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