Monthly Archives: November 2015

Hemorheological Disorders and Arteriolar Resistance During Ischemic Heart Disease

68T. Urdulashvili,  N. Momtselidze,
M. Mantskava, N. Narsia,
G. Mchedlishvili.

 

Microcirculation research Center, I.Beritashvili Institute of Physiology, Tbilisi, Georgia.
Internal Medicine, State medical University, Tbilisi, Georgia.

 

Abstract. It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, which a technique that provided us with the direct and quantitative data. Simultaneously we investigated in the some patients the tone of the resistance arteries of the hand with an original non-invasive technique. We found that the erythrocyte aggregability increased almost twice in the blood of investigated patients as compared to the healthy control group. The aggregability was positively correlated with severity of the disease.

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The most pronounced hemorheological disorders were found in the patients with the heart failure. As to the arteriolar resistance index, it was increased only in 45 per cent of all the investigated patients and no significant difference between the patients with the heart failure and without it was found available. We concludes that the blood rheological disorders represent themselves a factor that plays a significant role in pathogenesis of development of the heart disease.[/su_animate]

Coparative significance of the principal factors responsible for microcirculatory disirders in type 2 diabetes mellitus

61M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.

I.Beritashvilis institute of Physiology, Georgian Academy of Sciences, Tbilisi, Georgia
N. Bochua Georgian Center of Angiology and Vascular Surgery, Tbilisi, Georgia


The present study was aimed at investigating the comparative +changes of the two most significant microcirculatory factors if microvascular blood flow, possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus. By using direct quantitative and highly sensitive investigation techniques we found that insulin improves the blood rheological properties in the microcirculation altered during diabetes.
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However, when the disorders are strongly pronounced, due to enhanced red blood cells (RBC) aggregation, e.g., during development of the feet diabetic gangrene, the insulin becomes inefficient. As to the arteriolar tone, it seems to play less significant role in the pathogenesis of microcirculatory disturbances in diabetic patients.[/su_animate]

Regional and systemic hemorheological disorders during feet diabetic gangrene

67Nugzar Pargalava, Maya Mantskava,
George Mchedlishvili.


N. Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.
Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.

 

Abstract. We investigated the RBC aggregability in the patients with the foot diabetic gangrene in the venous blood samples taken from the damaged foot before its amputation, as well as from the cubital vein (the systemic circulation). The RBC aggregability was investigated with the “Georgian technique” that is sensitive and provided us with direct and quantitative data.we found that the RBC aggregability was higher by about 20%, in the blood flowing from the gangrenous tissue than in the systemic circulation.

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Therefore, the sources of the systemic hemorheological disorders were the primarily damaged tissues. Taking into account that the blood in uninterruptedly flowing and mixing together in the whole circulatory bed we conclude that in the systemic circulation a certain compensatory mechanism provide for a partial normalization of the blood rheological properties, since the RBC aggregability never reaches the level in the blood of the healthy people.[/su_animate]
Key words: Microvascular hemorheology, diabetic gangrene, RBC aggregation.

Direct Beneficial Effect of Insulin on Blood Rheologiacal Disorders in the Microcirculation

66Maya Mantskava, Nugzar Pargalava, 
George Mchedlishvili.


Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.
N, Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.

 

Abstract. Under both in vivo and in vitro conditions we investigated effect on the most significant factor disturbing the blood rheological disorders in the microcirculation, the red blood cell aggregability. The in vivo studies we carried out in the 42 insulin treated diabetic patients (diabetes mellitus type II), as well as conducted the in vitro investigations of the blood both of the diabetic patients (24) and of the healthy people (20) where the insulin was added to the blood in vivo.
   
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The RBC aggregability in blood investigated with the “Georgian technique” was found significantly enhanced, by about 100 per cents in the diabetic patients. Under the in vivo conditions insulin administrated intravenously decreased the RBC aggregability almost to the normal level in diabetic patients. In addition, in vitro studies we found that the insulin lowered significantly the RBC aggregability when it was significantly enhanced by addition of Dextran-500, as well as in the blood of patients with the ischemic brain infarcts. The decreasing effect on the aggregability was observed even in the healthy control group where the RBC aggregability was in a normal range.[/su_animate]

All entries on this site with the authors

M. Mantskava

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M. Mantskava – Doctor of Biological Sciences, Associate Professor. Member of the academic Council.
Center for experimental Biomedicine of the I. Beritashvili.
Georgia, Tbilisi, Gotua St. 14.

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Thyroid and periodontitis

Bood hemorheological status Bood hemorheological status during arterial hypertension

Stress – cause and effect hemorheological disorders

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Positive Effect of Bemiparin to Blood Flow

Hemorheological, microvascular and hemodynamic disorders during coronary heart disease

Parathyroid gland dysfunction and blood rheological changes in adolescents

Hemorheological Disorders and Arteriolar Resistance During Ischemic Heart Disease

Coparative significance of the principal factors responsible for microcirculatory disirders in type 2 diabetes mellitus

Regional and systemic hemorheological disorders during feet diabetic gangrene

Direct Beneficial Effect of Insulin on Blood Rheologiacal Disorders in the Microcirculation

Resistive arteries, normal function and pathological reactions

Assessment of a functional condition of resistive arteries at the person

Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene

The Positive Effect of Bemiparin to Blood Flow in the Experiment (Design research)

Complex Population Survey of Non-Invasive Arterial Elasticity, Vascular Wall Rigidity, Low Resistive Arteries Tonus and Other Parameters 

Role of various stressor in the starting mechanism of an illness of Reynaud (haemo rheological and vascular reactions)

Blood rheological status in obstruction apnea

Blood rheological properties in blood loss (An experimental study)

Microcirculation, blood rheology status and age-related changes

Hemorrhagic shock and stress – cause and effect on the example of violations of hemorheology changes erythrocyte aggregated

Hemorheological status of blood

Study of erythrocyte deformability at hemorrhagic shock

Hemorhoelogical status during periodontitis and without thyroid dysfunction betwen children the age of 11-13

Blood rheological status and Influence of grape seed extract in patients with parodontitis

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Study of hemorheological parameters at hemorrhagic shock

Reological disorders with preeclampsia

Safety of treatment of various diseases

Blood rheological status during treatment of arterial hypertension

Influence ofdifferent types of insulin on the aggregation of red blood cells in patients with diabetes

Reological disorders with preeclampsia

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Microvascular and Hemorheological disorders during ischemic heart disease

Comparative significance of the principal factors responsible for microcirculatory disorders in type 2 diabetes mellitus

Hemorheological, microvascular and hemodynamic disorders during coronary heart disease

Comparative values of erythrocyte aggregability versus other indices of hemorheological disorders in patients with ischemic brain infarcts

Arteriolar resistance and hemorheological disorders related to raynaud’s phenomenon

Hemorheological disorders and arteriolar resistance during ischemic heart disease

Direct beneficial effect of insulin on blood rheological disorders in the microcirculation

Regional and systemic hemorheological disorders during feet diabetic gangrene

Hemorheological disorders during ischemic brain infarcts in patients with and without diabetes mellitus

Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene

Hemorrhagic Shock and Stress – Cause and Consequence of Hemorheology Disturbances on the Example of the Changes in Erythrocyte Aggregation

The Role of Various Stressors in the Trigger Mechanism of Raynaud’s Disease (Hemorheological and Vascular Reactions)

Assessment of Platelet in Case of Stress-induced Apnea

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Resistive arteries, normal function and pathological reactions

59 Мchedlishvili G., Tsinamdzgvrishvili B., Mantskava M.

Our studies have shown pathogenic resistive functional characteristics of arteries in the body, which provide a normal and an abnormal pressure in microcirculation of organs. Our studies have shown pathogenic characteristics of the functional state of resistive arteries in the body, which provide a normal and an abnormal pressure in  microcirculation of organs. Furthermore, our studies have shown  changes of тче smooth muscle of resistive arteries, which cause pathological constriction. Based on this data, we developed a technique to determine the functional state of the resistance arteries.

 

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Microvascular and Hemorheological disorders during ischemic heart disease

18T. Urdulashvili, M. Mantskava,
N. Momtselidze, N. Narsia,
G. Mchedlishvili.

 

Scientific –Practical Journal ISSN 1512-1291.
Cardilogy and Internal Medicine XXIN4 (VIII) 2004, 9-15.


 

Significance of the hemorheological disorders in development of acute vascular syndromes is presenltky well known, but their role in pathogenesis of chronic ischemic heart disease is not yet sufficiently analyzed. Aim of the present study was investigation of the relationship between the hemorheological, vascular and hemodynamic factors during the ischemic heart disease.

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We investigated 64 patients with ischemic heart disease of functional classes I-IV with and without heart failure. For evaluation of the hemorheological disorders we investigated the most significant symptom, the erythrocyte aggregability, with the Georgian technique” that provided us with direct and quantitative data. In the some patients we investigated the tone of the resistance arteries with an original non-invasive technique. Based on measurement of[/su_animate]

Comparative significance of the principal factors responsible for microcirculatory disorders in type 2 diabetes mellitus

20M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.

 

The present study was aimed at investigated the comparative changes of the two most significant microcirculatory factors of microvascular blood flow. Possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus.

 

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By using direct quantitative and highly sensitive investigation techniques we found that insulin improves the blood rheological properties in the microcirculation altered during diabetes. However, when the disorders are strongly pronounced, due to enhanced red blood cells (RBC) aggregation, e.g., during development of the feet diabetic gangrene, the insulin becomes inefficient. As to the arteriolar tone, it seems to play less significant role in the pathogenesis of microcirculatory disturbances in diabetic patients.
Key words: Erythrocyte aggregation, diabetes mellitus, resistance of arterioles
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Hemorheological, microvascular and hemodynamic disorders during coronary heart disease

21Urdulashvili T., Momtselidze N.,
Mantskava M., Narsia N.,
Mchedlishvili G.

 


Georgian Med News.  2006; (136):55-7 (ISSN: 1512-0112)Department of Internal Medicine, State Medical University, Tbilisi, Georgia.

 

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Significance of the hemorheological disorders in development of acute vascular syndromes is presently well known, but their role in pathogenesis of chronic coronary heart disease has not been yet sufficiently analyzed. Aim of the present study was the investigation of the relationship between the hemorheological, vascular and hemo-dynamic factors responsible for development of the coronary heart disease. We investigated 64 patients with coronary heart disease of the functional classes I-IV with and without the heart failure.[/su_animate]

Comparative values of erythrocyte aggregability versus other indices of hemorheological disorders in patients with ischemic brain infarcts

22G. Mchedlishvili,  R. Shakarishvili,
N. Momtselidze, L. Gobejishvili,
M. Aloeva,  M. Mantskava.

 


Microcirculation Research Center, I. Beritashvili Institute of Physiology, Tbilisi, Georgia. Clinical hemorheology and microcirculation (Impact Factor: 3.4). 02/2000; 22(1):9-15.
Source: PubMed

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ABSTRACT The aim of the present study is comparison of changes of principal hemorheological factors responsible for blood flow disorders in the microcirculation in patients with ischemic brain infarcts. It was found that in venous blood samples the erythrocyte aggregability (examined with a direct, highly sensitive, quantitative technique) was considerably more increased (by mean of 120%) than the blood plasma fibrinogen contents, blood plasma viscosity, and hematocrit which increased only by 23.7%, 7.4% and 3.6%, respectively, as compared to the same hemorheological factors in the healthy controls. [/su_animate]

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