Tag Archives: study
Comparative significance of the principal factors responsible for microcirculatory disorders in type 2 diabetes mellitus
M. Mantskava, N. Momtselidze,
G. Mchedlishvili, N. Pargalava.
The present study was aimed at investigated the comparative changes of the two most significant microcirculatory factors of microvascular blood flow. Possibly producing severe disorders in blood supply to tissues in the diabetic patients – constriction of resistant arteries and the hemorheological disorders in the patients with the type 2 diabetes mellitus.
[su_animate type=”rotateInDownRight”]
By using direct quantitative and highly sensitive investigation techniques we found that insulin improves the blood rheological properties in the microcirculation altered during diabetes. However, when the disorders are strongly pronounced, due to enhanced red blood cells (RBC) aggregation, e.g., during development of the feet diabetic gangrene, the insulin becomes inefficient. As to the arteriolar tone, it seems to play less significant role in the pathogenesis of microcirculatory disturbances in diabetic patients.
Key words: Erythrocyte aggregation, diabetes mellitus, resistance of arterioles.[/su_animate]
Hemorheological disorders during ischemic brain infarcts in patients with and without diabetes mellitus
N. Momtselidze., M. Mantskava.,
G. Mchedlishvili.
Clinical hemorheology and microcirculation 2006;35(1-2):261-4.
Abstract
[su_animate type=”tada”]
The aim of the present study was the comparative analysis of the role of specific hemorheological derangements in the pathogenesis of ischemic brain infarcts with and without diabetes mellitus. Blood plasma viscosity, as well as red blood cells (RBC) aggregability were quantitatively investigated in all patients during the study. Both of the above mentioned indices of hemorheological disorders were significantly higher in the patients with brain infarcts and diabetes mellitus as compared to the control and the group of ischemic brain infarcts without diabetes.[/su_animate]
Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene
M. Mantskava., N. Momtselidze.,
N. Pargalava., G., Mchedlishvili.
Clinical hemorheology and microcirculation 2006;35(1-2):307-10.
Abstract
[su_animate type=”fadeInUp”]
The aim of the present study was to evaluate blood rheological disorders, in particular RBC enhanced aggregation, and compare changes in these parameters in patients with type 1 and 2 diabetes mellitus. For evaluation of RBC aggregability in the present study we applied the "Georgian technique", which was developed and applied for several years in our laboratory. Its advantage is that it is a direct and quantitative method. In all the investigated patients, diabetes mellitus was complicated with the foot gangrenes.[/su_animate]
Blood rheological properties in blood loss (An experimental study)
M. M. Mantskava, N. G. Momtselidze,
L. Sh. Davlianidze.
I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia; 14, L. Gotua, Tbilisi, Georgia
Blood loss is a complex pathological process with the mechanism that has not been fully unstudied. Blood rheology.biz is a particular link that is involved in blood losses. Objective: to perform a comprehensive study of blood rheological proper- ties, such as erythrocyte aggregability, erythrocyte deformability, plasma viscosity, and packed cell volume, in different degrees of experimental blood loss. [su_animate type=”bounceInDown”]
Materials and methods. Blood loss of different stages was simulated in anesthetized animals. The Georgian technique, membrane filtration, a capillary method, and a standard centrifugation method were used to study blood rheological properties. [/su_animate]
Reological disorders with preeclampsia
Mantskava M., Momtselidze N.
Berlin, Germany, 18-21 Mach, 2016 (16 World Congress on Human Reproduction)
The aim of the present study is comparison of changes of hemorheological functional condition responsible for blood flow disorders in the microcirculation in physiology pregnancy, pregnancy women with preeclampsia and control group. The principal factor of hemoreological was monitored RBC aggregation with the “Georgian technique” that is sensitive and provided us with direct and quantitative data.
[su_animate type=”slideInLeft”]We investigated 25 subjects with mean age 25,5±3,4 (physiological first pregnancy, 21 weeks, n=10; first pregnancy with preeclampsia, 21 weeks, n=8; control, n=7).[/su_animate]
Reological disorders with preeclampsia
Mantskava M., Momtselidze N.
Berlin, Germany, 18-21 Mach, 2016 (16 World Congress on Human Reproduction)
The aim of the present study is comparison of changes of hemorheological functional condition responsible for blood flow disorders in the microcirculation in physiology pregnancy, pregnancy women with preeclampsia and control group.
[su_animate type=”rotateInDownLeft”]
The principal factor of hemoreological was monitored RBC aggregation with the “Georgian technique” that is sensitive and provided us with direct and quantitative data. We investigated 25 subjects with mean age 25,5±3,4 (physiological first pregnancy, 21 weeks, n=10; first pregnancy with preeclampsia, 21 weeks, n=8; control, n=7). The analysis of the data was performed using statistical [/su_animate]
