Tag Archives: RBC
Regional and systemic hemorheological disorders during feet diabetic gangrene
Nugzar Pargalava, Maya Mantskava,
George Mchedlishvili.
N. Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.
Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.
Abstract. We investigated the RBC aggregability in the patients with the foot diabetic gangrene in the venous blood samples taken from the damaged foot before its amputation, as well as from the cubital vein (the systemic circulation). The RBC aggregability was investigated with the “Georgian technique” that is sensitive and provided us with direct and quantitative data.we found that the RBC aggregability was higher by about 20%, in the blood flowing from the gangrenous tissue than in the systemic circulation.
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Therefore, the sources of the systemic hemorheological disorders were the primarily damaged tissues. Taking into account that the blood in uninterruptedly flowing and mixing together in the whole circulatory bed we conclude that in the systemic circulation a certain compensatory mechanism provide for a partial normalization of the blood rheological properties, since the RBC aggregability never reaches the level in the blood of the healthy people.[/su_animate]
Key words: Microvascular hemorheology, diabetic gangrene, RBC aggregation.
Direct Beneficial Effect of Insulin on Blood Rheologiacal Disorders in the Microcirculation
Maya Mantskava, Nugzar Pargalava,
George Mchedlishvili.
Microcirculation Research Center, I.Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia.
N, Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia.
Abstract. Under both in vivo and in vitro conditions we investigated effect on the most significant factor disturbing the blood rheological disorders in the microcirculation, the red blood cell aggregability. The in vivo studies we carried out in the 42 insulin treated diabetic patients (diabetes mellitus type II), as well as conducted the in vitro investigations of the blood both of the diabetic patients (24) and of the healthy people (20) where the insulin was added to the blood in vivo.
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The RBC aggregability in blood investigated with the “Georgian technique” was found significantly enhanced, by about 100 per cents in the diabetic patients. Under the in vivo conditions insulin administrated intravenously decreased the RBC aggregability almost to the normal level in diabetic patients. In addition, in vitro studies we found that the insulin lowered significantly the RBC aggregability when it was significantly enhanced by addition of Dextran-500, as well as in the blood of patients with the ischemic brain infarcts. The decreasing effect on the aggregability was observed even in the healthy control group where the RBC aggregability was in a normal range.[/su_animate]
Direct beneficial effect of insulin on blood rheological disorders in the microcirculation
M. Mantskava, N. Pargalava,
G. Mchedlishvili.
Clinical hemorheology and microcirculation 2004;30(3-4):431-3.
Abstract
Under both the in vivo and in vitro conditions we investigated the insulin effect on the most significant factor disturbing the blood rheological disorders in the microcirculation, the red blood cell aggregability.
[su_animate type=”slideInRight”]The in vivo studies we carried out in the 42 insulin treated diabetic patients (diabetes mellitus type II), as well as conducted the in vitro investigations of the blood both of the diabetic patients (24) and of the healthy people (20) where the insulin was added to the blood ex vivo. The RBC aggregability in blood investigated with the “Georgian technique” was found significantly enhanced, by about 100 per cents in the diabetic patients.[/su_animate]
Regional and systemic hemorheological disorders during feet diabetic gangrene.
N. Pargalava., Maya Mantskava.,
George Mchedlishvili.
Clinical hemorheology and microcirculation 2004;30(3-4):457-9.
Abstract
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We investigated the RBC aggregability in the patients with the foot diabetic gangrenes: in the venous blood samples taken from the damaged foot before its amputation, as well as from the cubital vein (the systemic circulation). The RBC aggregability was investigated with the "Georgian technique" that is sensitive and provided us with direct and quantitative data. We found that the RBC aggregability was higher by about 20%, in the blood flowing from the gangrenous tissue than in the systemic circulation.[/su_animate]
Hemorheological disorders during ischemic brain infarcts in patients with and without diabetes mellitus
N. Momtselidze., M. Mantskava.,
G. Mchedlishvili.
Clinical hemorheology and microcirculation 2006;35(1-2):261-4.
Abstract
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The aim of the present study was the comparative analysis of the role of specific hemorheological derangements in the pathogenesis of ischemic brain infarcts with and without diabetes mellitus. Blood plasma viscosity, as well as red blood cells (RBC) aggregability were quantitatively investigated in all patients during the study. Both of the above mentioned indices of hemorheological disorders were significantly higher in the patients with brain infarcts and diabetes mellitus as compared to the control and the group of ischemic brain infarcts without diabetes.[/su_animate]
Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene
M. Mantskava., N. Momtselidze.,
N. Pargalava., G., Mchedlishvili.
Clinical hemorheology and microcirculation 2006;35(1-2):307-10.
Abstract
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The aim of the present study was to evaluate blood rheological disorders, in particular RBC enhanced aggregation, and compare changes in these parameters in patients with type 1 and 2 diabetes mellitus. For evaluation of RBC aggregability in the present study we applied the "Georgian technique", which was developed and applied for several years in our laboratory. Its advantage is that it is a direct and quantitative method. In all the investigated patients, diabetes mellitus was complicated with the foot gangrenes.[/su_animate]
Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene
Maya Mantskava, Nana Momtselidze, Nugzar Pargalava, George Mchedlishvili.
Microcirculation Research Center, I. Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia
N. Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia
Abstract. The aim of the present study was to evaluate blood rheological disorders, in particular RBC enhanced aggregation, and compare changes in these parameters in patients with type I and II diabetes mellitus. For evaluation of RBC aggregability in the present study we applied the “Georgian technique”, which was developed and applied for several years in our laboratory. Its advantage is that it is a direct and quantitative method. In all the investigated patients, diabetes mellitus was compared with the foot gangrenes. The patients were divided into two groups: (a) with type I and with type II diabetes mellitus. We matched the RBC aggregability indices in both groups of diabetic patients and compared the obtained results with those in the healthy control group. We found that rheological disorders were considerably pronounced.
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The RBC aggregability index increased by 62 per cent (p<0.001) in type I and by 57 per cent (p<0.001) in type II diabetic patients as compared to the control group. However, there were insignificant differences of the RBC aggregability changes between the two groups of the patients. Therefore we conclude that blood rheological disorders are similar in both types of diabetes mellitus. The disturbed blood fluidity related to the increased RBC aggregability in the microcirculation promotes, in particular, the development of the gangrene in both types of diabetes mellitus.Text[/su_animate]
