Tag Archives: parameters
Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene
M. Mantskava., N. Momtselidze.,
N. Pargalava., G., Mchedlishvili.
Clinical hemorheology and microcirculation 2006;35(1-2):307-10.
Abstract
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The aim of the present study was to evaluate blood rheological disorders, in particular RBC enhanced aggregation, and compare changes in these parameters in patients with type 1 and 2 diabetes mellitus. For evaluation of RBC aggregability in the present study we applied the "Georgian technique", which was developed and applied for several years in our laboratory. Its advantage is that it is a direct and quantitative method. In all the investigated patients, diabetes mellitus was complicated with the foot gangrenes.[/su_animate]
Assessment of a functional condition of resistive arteries at the person
G. Mchedlishvili, M. Mantskava,
T. Urdulashvili.
It is notable that the resistance arteries play the leading part in regulation of physiological parameters of the circulation system. It is proposed a new noninvasive method of appraisal of functional state of the human arm resistance arteries. The method is based on research of postischematic hyperemia arising as a result of standard stopping of local blood flow for one minute. The measurement of blood flow velocity in the radial artery of patients is performed by means of ultrasonic device which work is based on Doppler’s effect. For determination of functional state of the resistance arteries a new notion of resistance index is introduced. By this parameter the state of resistance arteries of human arm is investigated at different diseases (Raynaud’s phenomenon, arterial hypertension, diabetes mellitus, etc.).
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Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene
Maya Mantskava, Nana Momtselidze, Nugzar Pargalava, George Mchedlishvili.
Microcirculation Research Center, I. Beritashvili Institure of Physiology, 14 Gotua St., 0160, Tbilisi, Georgia
N. Bochua Center of Angiology and Vascular Surgery, 1. Chachava St., 0159, Tbilisi, Georgia
Abstract. The aim of the present study was to evaluate blood rheological disorders, in particular RBC enhanced aggregation, and compare changes in these parameters in patients with type I and II diabetes mellitus. For evaluation of RBC aggregability in the present study we applied the “Georgian technique”, which was developed and applied for several years in our laboratory. Its advantage is that it is a direct and quantitative method. In all the investigated patients, diabetes mellitus was compared with the foot gangrenes. The patients were divided into two groups: (a) with type I and with type II diabetes mellitus. We matched the RBC aggregability indices in both groups of diabetic patients and compared the obtained results with those in the healthy control group. We found that rheological disorders were considerably pronounced.
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The RBC aggregability index increased by 62 per cent (p<0.001) in type I and by 57 per cent (p<0.001) in type II diabetic patients as compared to the control group. However, there were insignificant differences of the RBC aggregability changes between the two groups of the patients. Therefore we conclude that blood rheological disorders are similar in both types of diabetes mellitus. The disturbed blood fluidity related to the increased RBC aggregability in the microcirculation promotes, in particular, the development of the gangrene in both types of diabetes mellitus.Text[/su_animate]
Question-answer
What determines blood rheological properties?
Hemorheological parameters determine blood rheological properties.
What determines blood rheological status?
1. Hematocrit.
2. Blood viscosity.
3. Еrythrocyte agregability.
4. Erythrocyte deformability.
What is the danger of causing rheological disorders?
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Increased erythrocyte aggregation, decreased erythrocyte deformation, changed hematocrit and plasma viscosity leads to a blockage of capillaries, a slowed down blood flow and develops a capillary stasis. The result is a lack of oxygen. During erythrocyte aggregation erythrocytes may get damaged and an erythrocyte coagulation factor may be developed, which could cause a rheological catastrophe.[/su_spoiler]
Study of erythrocyte deformability at hemorrhagic shock
M. Mantskava, N. Momtselidze,
L. Davlianidze.
I.Beritashvili Center of Experimental Biomedicine, 14 Gotua St., Tbilisi, Georgia, 0160.
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The aim of our work was a red blood cell deformation (rheological rheological ) at rheological degrees of severity of experimental hemorrhagic shock. The study of erythrocyte deformability violation and a compulsory monitoring of this physical value deserve more attention of fundamental and applied sciences. The modeling of hemorrhagic shock of different stages was performed in the group of anesthetized animals by means of standard blood discharge from the femoral artery (2,5 ml – first stage of shock; 5 ml – second stage of shock; 5ml – third stage of shock, n=12).[/su_animate]
