Tag Archives: disease

Hemorheological, microvascular and hemodynamic disorders during coronary heart disease

57Urdulashvili T., Momtselidze N.,
Mantskava M., Narsia N.,
Mchedlishvili G.

 

Department of Internal Medicine, State Medical University; Microcirculation Research    Center, I. Beritashvili Institute of Physiology, Tbilisi,  Georgia.

Coronary artery disease (CAD) is the leading cause of cardiovascular mortality worldwide. Even more, it is projected that CAD mortality rates will double from 1990 to 2020, with approximately 82% of the increase attributable to the developing world [5]. Prevention and targeted control of risk factors for CAD could potentially reduce the impact of CAD in the developing world.
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Many scientists indicate the significance of the monitoring of hemorheological patterns during various forms of the ischemic heart disease [2,6]. The increased RBC aggregation was observed in the patients in the following order: unstable angina, acute myocardial inf- arct. The best correlation was observed by integration of large aggregate fraction as a function of shear stress [1].[/su_animate]

Hemorheological Disorders and Arteriolar Resistance During Ischemic Heart Disease

68T. Urdulashvili,  N. Momtselidze,
M. Mantskava, N. Narsia,
G. Mchedlishvili.

 

Microcirculation research Center, I.Beritashvili Institute of Physiology, Tbilisi, Georgia.
Internal Medicine, State medical University, Tbilisi, Georgia.

 

Abstract. It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, which a technique that provided us with the direct and quantitative data. Simultaneously we investigated in the some patients the tone of the resistance arteries of the hand with an original non-invasive technique. We found that the erythrocyte aggregability increased almost twice in the blood of investigated patients as compared to the healthy control group. The aggregability was positively correlated with severity of the disease.

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The most pronounced hemorheological disorders were found in the patients with the heart failure. As to the arteriolar resistance index, it was increased only in 45 per cent of all the investigated patients and no significant difference between the patients with the heart failure and without it was found available. We concludes that the blood rheological disorders represent themselves a factor that plays a significant role in pathogenesis of development of the heart disease.[/su_animate]

Microvascular and Hemorheological disorders during ischemic heart disease

18T. Urdulashvili, M. Mantskava,
N. Momtselidze, N. Narsia,
G. Mchedlishvili.

 

Scientific –Practical Journal ISSN 1512-1291.
Cardilogy and Internal Medicine XXIN4 (VIII) 2004, 9-15.


 

Significance of the hemorheological disorders in development of acute vascular syndromes is presenltky well known, but their role in pathogenesis of chronic ischemic heart disease is not yet sufficiently analyzed. Aim of the present study was investigation of the relationship between the hemorheological, vascular and hemodynamic factors during the ischemic heart disease.

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We investigated 64 patients with ischemic heart disease of functional classes I-IV with and without heart failure. For evaluation of the hemorheological disorders we investigated the most significant symptom, the erythrocyte aggregability, with the Georgian technique” that provided us with direct and quantitative data. In the some patients we investigated the tone of the resistance arteries with an original non-invasive technique. Based on measurement of[/su_animate]

Hemorheological, microvascular and hemodynamic disorders during coronary heart disease

21Urdulashvili T., Momtselidze N.,
Mantskava M., Narsia N.,
Mchedlishvili G.

 


Georgian Med News.  2006; (136):55-7 (ISSN: 1512-0112)Department of Internal Medicine, State Medical University, Tbilisi, Georgia.

 

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Significance of the hemorheological disorders in development of acute vascular syndromes is presently well known, but their role in pathogenesis of chronic coronary heart disease has not been yet sufficiently analyzed. Aim of the present study was the investigation of the relationship between the hemorheological, vascular and hemo-dynamic factors responsible for development of the coronary heart disease. We investigated 64 patients with coronary heart disease of the functional classes I-IV with and without the heart failure.[/su_animate]

Hemorheological disorders and arteriolar resistance during ischemic heart disease

26T. Urdulashvili., N. Momtselidze.,
M. Mantskava., N. Narsia.,
G. Mchedlishvili.

 


Clinical hemorheology and microcirculation 2004;30(3-4):399-401.

Abstract

 

 

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It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, with a technique that provided us with the direct and quantitative data.[/su_animate]