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Hemorheological Disorders and Arteriolar Resistance During Ischemic Heart Disease
T. Urdulashvili, N. Momtselidze,
M. Mantskava, N. Narsia,
G. Mchedlishvili.
Microcirculation research Center, I.Beritashvili Institute of Physiology, Tbilisi, Georgia.
Internal Medicine, State medical University, Tbilisi, Georgia.
Abstract. It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, which a technique that provided us with the direct and quantitative data. Simultaneously we investigated in the some patients the tone of the resistance arteries of the hand with an original non-invasive technique. We found that the erythrocyte aggregability increased almost twice in the blood of investigated patients as compared to the healthy control group. The aggregability was positively correlated with severity of the disease.
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The most pronounced hemorheological disorders were found in the patients with the heart failure. As to the arteriolar resistance index, it was increased only in 45 per cent of all the investigated patients and no significant difference between the patients with the heart failure and without it was found available. We concludes that the blood rheological disorders represent themselves a factor that plays a significant role in pathogenesis of development of the heart disease.[/su_animate]
Hemorheological disorders and arteriolar resistance during ischemic heart disease
T. Urdulashvili., N. Momtselidze.,
M. Mantskava., N. Narsia.,
G. Mchedlishvili.
Clinical hemorheology and microcirculation 2004;30(3-4):399-401.
Abstract
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It could be conjectured that the hemorheological disorders are involved in development of the ischemic heart disease. But this fact was so far insufficiently cleared up. The present studies were carried out in patients with various forms of chronic ischemic heart disease. We investigated the most significant factor of rheological disorders in the microcirculation, the erythrocyte aggregability, with a technique that provided us with the direct and quantitative data.[/su_animate]
Direct beneficial effect of insulin on blood rheological disorders in the microcirculation
M. Mantskava, N. Pargalava,
G. Mchedlishvili.
Clinical hemorheology and microcirculation 2004;30(3-4):431-3.
Abstract
Under both the in vivo and in vitro conditions we investigated the insulin effect on the most significant factor disturbing the blood rheological disorders in the microcirculation, the red blood cell aggregability.
[su_animate type=”slideInRight”]The in vivo studies we carried out in the 42 insulin treated diabetic patients (diabetes mellitus type II), as well as conducted the in vitro investigations of the blood both of the diabetic patients (24) and of the healthy people (20) where the insulin was added to the blood ex vivo. The RBC aggregability in blood investigated with the “Georgian technique” was found significantly enhanced, by about 100 per cents in the diabetic patients.[/su_animate]
